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The last time they meet was in week 17 of 2006, Peyton Manning threw two touchdowns and the Colts defeated the Dolphins, 27-22 completing their first perfect home campaign since 1958.
The Dolphins have won four of the last six meetings, this is including the 2000 AFC wild card matchup won by the Dolphins, overall series lead to 46-23.

The Dolphins uncharacteristically turned the ball over four times last week, leading to a 19-7 road loss to the Falcons. On the other side Reggie Wayne caught 10 passes for 162 yards and a touchdown, providing just enough of a cushion for the Colts to hold on for a 14-12 home win over the Jacksonville Jaguars.
The Indianapolis Colts wide receiver Anthony Gonzalez was expected to play a major role in the Colts’ aerial attack this season, but a knee injury will sideline him indefinitely. In the meantime, the Colts will look to rookie Austin Collie and second year receiver Pierre Garcon — two players with a combined nine career receptions — to fill the void alongside Wayne and tight end Dallas Clark.

Indianapolis was never known as a heavy defensive unit under former coach Tony Dungy’s Tampa, but new coach Jim Caldwell has his defense playing a more aggressive zone scheme. Despite recording only one sack against Jacksonville, the Colts harassed Jaguars QB David Garrard all day and stacked the box against Maurice Jones-Drew and the ground game. Dolphins quarterback Chad Pennington is not prone to making many mistakes, but coming off a two-turnover performance against Atlanta, he’s likely to face plenty of pressure.

Dolphins plus-17 turnover ratio was the best in the league last season, but that did not carry over into Week 1. Miami committed four turnovers (three fumbles, one interception) against the Falcons last week. They’ll need to fix that issue quickly to prove that 2008 wasn’t a fluke.